Collin Klein rushed for four touchdowns and threw another as K-State dismantled Kansas, 59-21 in Lawrence.
The Wildcats moved to 7-0 for the first time this decade and the return of Bill Snyder.
The Jayhawks (2-5) have now lost five straight games and still hold the nations worst defense, giving up 466 yards of total offense and over 42 points.
Klein leads the Big 12 in touchdowns with 14 touchdowns.
K-State outscored KU 45-14 in the second and third quarters combined. Statistically the third quarter has been the worst for the Jayhawks.
The Wildcats led 21-0 in the first quarter before KU scored their first touchdown on a James Sims run.
Kansas trailed 31-14 at halftime but had life until K-State returned the kickoff and the route was on from there.
The Jayhawks will play Texas next week in Austin while K-State hosts #3 Oklahoma in Manhattan.
Kansas and Kansas State are halfway done with the 109th meeting of the Sunflower Showdown, and so far, it's been the Wildcats controlling the game.
Scoring got underway when K-State quarterback Collin Klein scored from seven yards out on a quarterback keeper to give the Wildcats a 7-0 lead.
KU was unable to get anything going offensively, and was hampered by multiple penalties, forcing the Jayhawks to punt the ball back to K-State with good field position.
Klein was able to capitalize on that position, and led K-State to another scoring drive, this time capped off with a six yard keeper to put the 'Cats up 14-0 just five second into the second quarter.
The Wildcats got another score by doing more of the same. A Jayhawk three-and-out gave the Cats the ball back, and this time running back John Hubert got the score from five yards out to help the Cats take a 21-point lead.
Kansas finally got on the scoreboard on the next drive, putting together an 11-play, 63 yard drive that was finished off with a James Sims two-yard dive to bring the Jayhawks to within 14 points, 21-7.
K-State answered with an 8-play, 76 yard drive that again saw Klein in the endzone, giving him three first-half touchdowns, and the Wildcats a 28-7 lead.
But Kansas wasn't going to go quietly into the half. KU quarterback Jordan Webb found DJ Beshears for a 13-yard touchdown pass with only 14 seconds remaining in the half to get the Hawks back in the game, trailing 28-14, and the half appeared to be over.
At least that's what KU thought. K-State needed only one play to go from the KU 43 to their own 9-yard line, as Klein found Tyler Lockett in the air, and put the Cats in field goal position.
Wichita native Anthony Cantele hit the chip-shot field goal as time expired to put K-State up 31-14 at the half.
K-State is led in rushing by Klein who has eight carries for 62 yards and three touchdowns. Klein has also passed for 176 yards, a career high. Lockett has four receptions for 91 yards.
Kansas is led in rushing by Darrian Miller, who has eight carries for 19 yards, while Webb has thrown for 146 yards and a touchdown. Kale Pick has six receptions for 51 yards.